Industrial Revolution Essay -- essays papers

Industrial Revolution â€Å"Industrial Revolution†, in my opinion, is not a correct term. It makes it sound as though the whole thing happened at once, which it did not. It was rather an industrial evolution, or better yet an industrial chain reaction. One event impacted others and these changes impacted yet others. There were many important inventions during this time period. These inventions all made life a little easier for the people living during this time. There was an increasing demand for new material for clothing. The invention of the spinning jenny and powered loom made this possible. Steam engines provided power for machines. The cotton gin was another important invention. The Cotton gin made it possible to make clothes out of cotton, instead of the scratchy wool that clothes had always been made out of. Railroads were a very important invention during this century. Before the railroad was invented, people who lived away from their families never saw them. There simply was no easy way for them to visit. By 1869, railroads could go coast to coast in six and a half days. This is one way that the Industrial Revolution impacted social aspects of people’s lives. The Industrial Revolution did not only provide positive changes. There were also many negative changes. However, when you’re dealing with something that is going to change people’s lives to this degree, some downfalls can be expected. The industrial r...

Haemochromatosis

In medicine, Iron overload Indicates accumulation of iron In the body from any cause. The most important causes are hereditary haemochromatosis, a genetic disorder. and transfusional Iron overload, which can result from repeated blood transfusion. Terminology Haemochromatosis or haemoslderosls Historically, the term haemochromatosis was initially used to refer to what is now more specifically called haemochromatosis type 1 . Currently, haemochromatosis Is mostly defined as iron overload with a hereditary/primary cause, or originating from a metabolic disorder.However, the term is currently also used more broadly to refer o any form of Iron overload, thus requiring specification of the cause, for example, hereditary haemochromatosis. Hereditary haemochromatosis is an autosomal recessive disorder with estimated prevalence In the population of 1 In 200 among patients with European ancestry, with lower incidence in other ethnic groups. The gene responsible for hereditary haemochromatosis is located on chromosome 6; the majority of hereditary haemochromatosis patients have mutations in this HFE gene.Hereditary haemochromatosis Is characterized by an accelerated rate of Intestinal iron absorption and progressive iron deposition in various tissues that typically egins to be expressed in the third to fifth decades of life, but may occur In children. The most common presentation is hepatic cirrhosis in combination with hypopituitarism, cardiomyopathy, diabetes, arthritis, or hyperpigmentation. Because of the severe sequelae of this disorder if left untreated, and recognizing that treatment is relatively simple, early diagnosis before symptoms or signs appear is Important.In general, the term haemoslderosls Is used to Indicate the pathological effect of iron accumulation in any given organ, which mainly occurs in the form of haemoslderln. Sometimes, the simpler term siderosls Is used Instead. Other definitions distinguishing haemochromatosis or haemosiderosis that are oc casionally used include: Haemosiderosis Is haemochromatosis caused by excessive blood transfusions, that is, haemosiderosis is a form of secondary haemochromatosis.Haemoslderosls is haemoslderln deposition within cells, while haemochromatosis Is haemosiderin within cells and interstitium. Haemosiderosis is iron overload that does not cause tissue damage, while haemochromatosis does. Haemosiderosis Is arbitrarily differentiated from haemochromatosis by the reversible nature of the iron accumulation In the reticuloendothelial system. Clinical presentation Organs commonly affected by haemochromatosis are the liver, heart, and endocrine glands.Haemochromatosis may present with the following clinical syndromes: Cirrhosis of the liver Diabetes due to pancreatic islet cell failure Cardiomyopathy Arthritis Testicular failure Tanning of the skin Joint pain and bone pain 1 OF3 causes The causes can be distinguished between primary cases and less frequent secondary cases . People of Celtic, Br itish, and Scandinavian origin have a particularly high incidence of whom about 10% are carriers of the gene and 1% sufferers from the condition.Primary haemochromatosis The fact that most cases of haemochromatosis were inherited was well known for most of the 20th century, though they were incorrectly assumed to depend on a single gene. The overwhelming majority actually depend on mutations of the HFE gene discovered in 1996, but since then others have been discovered and sometimes are grouped together as â€Å"non-classical hereditary haemochromatosis†, â€Å"non-HFE related hereditary haemochromatosis†, or â€Å"non-HFE haemochromatosis†. Most types of hereditary haemochromatosis have autosomal recessive inheritance, while type 4 has autosomal dominant inheritance.Secondary haemochromatosis Severe chronic haemolysis of any cause, including intravascular haemolysis and ineffective erythropoiesis Multiple frequent blood transfusions, which are usually needed ei ther by individuals with hereditary anaemias or by older patients with severe acquired anaemias such as in myelodysplastic syndromes Excess parenteral iron supplements, such as what can acutely happen in iron poisoning Excess dietary iron Some disorders do not normally cause haemochromatosis on their own, but may do so in the presence of other predisposing factors.These include cirrhosis, teatohepatitis of any cause, porphyria cutanea tarda, prolonged haemodialysis, and post-portacaval shunting. Diagnosis There are several methods available for diagnosing and monitoring iron loading including: Serum ferritin Liver biopsy MRI Serum ferritin is a low-cost, readily available, and minimally invasive method for assessing body iron stores.However, the major problem with using it as an indicator of iron overload is that it can be elevated in a range of other medical conditions unrelated to iron levels including infection, inflammation, fever, liver disease, renal disease, and cancer. Also, total iron binding capacity may be low, but can also be normal. The standard of practice in diagnosis of haemochromatosis was recently reviewed by Pietrangelo. has been extensively validated. More than 11,000 FerriScans have now been conducted in over 120 medical centres across 25 countries.FerriScan is now specifically recommended as a method to measure liver iron concentrations in clinical practice guidelines for thalassaemias, sickle cell disease myelodysplastic syndrome and hereditary haemochromatosis. Family members of those diagnosed with primary haemochromatosis may be advised to be screened genetically to etermine if they are a carrier or if they could develop the disease. This can allow preventative measures to be taken. Prognosis A third of those untreated develop hepatocellular carcinoma.

The Nanking Massacre of 1937

In late December  1937 and early January  1938, the Imperial Japanese Army perpetrated one of the most horrific war crimes of the World War II era. In what is known as the Nanking Massacre or the Rape of Nanking, Japanese soldiers systematically raped thousands of Chinese women and girls of all ages - even infants. They also murdered hundreds of thousands of civilians and prisoners of war in what was then the Chinese capital city of Nanking (now called Nanjing).   These atrocities continue to color Sino-Japanese relations to this day. Indeed, some Japanese public officials have denied that the Nanking Massacre ever happened, or significantly downplay its scope and severity.  History textbooks in Japan mention the incident only in a single footnote, if at all. It is crucial, however, for the nations of East Asia to confront and move past the gruesome events of the mid-20th century  if they are going to face the challenges of the 21st century together. So what really happened to the people of Nanking in 1937-38? Japans Imperial Army invaded civil-war-torn China in July of 1937 from Manchuria  to the north.  It drove southward, quickly taking the Chinese capital city of Beijing. In response, the Chinese Nationalist Party moved the capital to the city of Nanking, about 1,000 km (621 miles) to the south. The Chinese Nationalist Army or Kuomintang (KMT) lost the key city of Shanghai to the advancing Japanese in November of 1937.  KMT leader Chiang Kai-shek realized that the new Chinese capital of Nanking, just 305 km (190 miles) up the Yangtze River from Shanghai, could not hold out much longer. Rather than wasting his soldiers in a futile attempt to hold Nanking, Chiang decided to withdraw most of them inland about 500 kilometers (310 miles) west to Wuhan, where the rugged interior mountains offered a more defensible position. KMT General Tang Shengzhi was left to defend the city, with an untrained force of 100,000 poorly-armed fighters.   The approaching Japanese forces were under the temporary command of Prince Yasuhiko Asaka, a right-wing militarist and the uncle by marriage of Emperor Hirohito.  He was standing in for the elderly General Iwane Matsui, who was ill. Early in December, division commanders informed Prince Asaka that the Japanese had encircled almost 300,000 Chinese troops around Nanking and inside the city. They told him that the Chinese were willing to negotiate a surrender; Prince Asaka responded with an order to kill all captives. Many scholars view this order as an invitation to the Japanese soldiers to go on a rampage in Nanking. On December 10, the Japanese mounted a five-pronged attack on Nanking.  By December 12, the besieged Chinese commander, General Tang, ordered a retreat from the city. Many of the untrained Chinese conscripts broke ranks and ran, and Japanese soldiers hunted them down and captured or slaughtered them. Being captured was no protection  because the Japanese government had declared that international laws on treatment of POWs did not apply to the Chinese. An estimated 60,000 Chinese fighters who surrendered were massacred by the Japanese. On December 18, for example, thousands of young Chinese men had their hands tied behind them, then were tied into long lines and marched to the Yangtze River. There, the Japanese opened fire on them en masse. The screams of the injured went on for hours, as the Japanese soldiers made their leisurely way down the lines to bayonet those who were still alive, and dump the bodies into the river. Chinese civilians also faced horrific deaths as the Japanese occupied the city.  Some were blown up with mines, mowed down in their hundreds with machine guns, or sprayed with gasoline and set on fire.  F. Tillman Durdin, a reporter for the New York Times who witnessed the massacre, reported: In taking over Nanking the Japanese indulged in slaughters, looting and rapine exceeding in barbarity any atrocities committed up to that time in the course of the Sino-Japanese hostilities... Helpless Chinese troops, disarmed for the most part and ready to surrender, were systematically rounded up and executed... Civilians of both sexes and all ages were also shot by the Japanese. Bodies piled up in streets and alleyways, too many for any accurate count. Perhaps equally horrifying, the Japanese soldiers made their way through entire neighborhoods systematically raping every female they found.  Infant girls had their genitals sliced open with swords to make it easier to rape them. Elderly women were gang-raped and then killed. Young women might be raped and then taken away to the soldiers camps for weeks of further abuse. Some sadistic soldiers forced celibate Buddhist monks and nuns to perform sex acts for their amusement, or forced family members into incestuous acts. At least 20,000 women were raped, according to most estimates. Between December 13, when Nanking fell to the Japanese, and the end of February  1938, the orgy of violence by the Japanese Imperial Army claimed the lives of an estimated 200,000 to 300,000 Chinese civilians and prisoners of war.  The Nanking Massacre stands as one of the worst atrocities of the bloody twentieth century. General Iwane Matsui, who had recovered from his illness somewhat by the time Nanking fell, issued several orders between December 20, 1937 and February of 1938 demanding that his soldiers and officers behave properly.  However, he was not able to bring them under control. On February 7, 1938, he stood with tears in his eyes and upbraided his subordinate officers for the massacre, which he believed had done irreparable damage to the Imperial Armys reputation. He and Prince Asaka were both recalled to Japan later in 1938; Matsui retired, while Prince Asaka remained a member of the Emperors War Council. In 1948, General Matsui was found guilty of war crimes by the Tokyo War Crimes Tribunal  and was hanged at the age of 70.  Prince Asaka escaped punishment  because the American authorities decided to exempt members of the imperial family. Six other officers and former Japanese Foreign Minister Koki Hirota were also hanged for their roles in the Nanking Massacre, and eighteen more were convicted but got lighter sentences.